The Edmonton Protocol, which has gained international recognition for the development of a specific and detailed procedure for replacement of insulin producing cells, pancreatic islets, into patients with longstanding and brittle Type 1 diabetes. Over 100 patients have received the islet transplant procedure in Edmonton and over 80% of these patients remain free of insulin injections at one year post islet transplant. Those programs which have successfully replicated the Edmonton protocol for the treatment of type 1 diabetes, have worked closely with our program, we have provided much of the specialized equipment and provided specific procedures. The Edmonton Protocol clinical islet transplant procedure has recently been recognized by the Province of Alberta as an essential service for Albertans with brittle longstanding Type 1 diabetes. The Edmonton Protocol team ahs also worked with programs in the United States that are working for establishing Medicare and private insurance companies to cover the transplant procedure.