Scientifically based, medically proven treatment capable of preventing, stopping, slowing, and reversing serious complications of diabetes.

CHRONIC INTERMITTENT INTRAVENOUS INSULIN THERAPY (CIIIT), also referred as  PIVIT (Pulsed Intravenous Insulin Therapy) or METABOLIC RESTORATION THERAPY (MRT), hepatic activation or metabolic activation, involves delivering insulin intravenously over a 3-4 hours period, in a pulsatile fashion using a specialized pump* controlled by a computerized program that adjusts the dosages based on frequent blood glucose monitoring. The pulses are designed to deliver a higher, more physiologic concentration of insulin to the liver than is delivered by traditional subcutaneous injections. This higher level of insulin is thought to more closely mimic the body’s natural levels of insulin as they are delivered to the liver. It is hoped that this therapy ultimately results in improved glucose control through improved hepatic activation.

PIVIT is typically delivered once weekly as an outpatient therapy.

MRT (Metabolic Restoration Therapy) is the only therapy proven to prevent, slow, stop or reverse the serious and often deadly complications of this disease (damage to the eyes, kidneys, nerves, heart, etc.). MRT is different from all other insulin treatments and therapies. The reason is simple; MRT is the only diabetes treatment that replicates the way the normal pancreas delivers insulin in a series of concentrated pulses directly into the bloodstream. MRT does not chase blood glucose numbers; it fundamentally changes the way glucose is managed and metabolized throughout the entire body and especially in the liver.

It is well known that the most important organ in the body for controlling the metabolism, storage, release and synthesis of glucose is the liver. Up to 80% of the insulin the pancreas secretes performs all its function within the liver and never makes it to the rest of the body. For the liver to function normally, it MUST receive pulses of insulin from the pancreas approximately once every 6 minutes when a meal is ingested. The carbohydrates from the meal along with insulin pulses are  important “signals” for the liver to process the nutrients properly.

MRT is administered using a unique insulin infusion device that is entirely different from all insulin pumps. The MRT device delivers insulin intravenously, saving the patient from having to give themselves multiple injections. Delivering insulin in this manner cannot be achieved using any other available insulin delivery system including syringes, insulin pens or pumps that administer insulin subcutaneously. MRT is the only diabetes treatment that focuses on normalizing carbohydrate metabolism, the core problem. In fact, MRT was developed, tested and used in private research clinics to treat patients who failed to fully  respond to conventional and intensive therapies.

During each weekly treatment, the MRT device delivers concentrated pulses of intravenous insulin every 6 minutes for 30 minutes after the ingestion of a glucose “meal”. A treatment process is followed by a “rest ” and this is repeated three times for a total of three hours.

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BENEFITS AND INDICATIONS FOR MRT:

Research has dramatically increased our understanding of diabetic metabolism, yet conventional treatments continue to focus solely on blood sugar control and not the correction of metabolic abnormalities. High blood sugars result from abnormal metabolism; MRT is the only therapy that focuses on normalizing metabolism.

Without adequate treatment, Type 1 individuals who are consistently exhibiting extremely high blood sugar levels are prone to coma with the potential of neurological damage and death. Type 2 individuals can experience a particularly lethal type of coma which can be fatal in up to 50% of the victims. Type 1 and Type 2 diabetes are life-long illnesses that require a serious commitment to proper management if complications are to be minimized or delayed. MRT is effective in preventing, slowing, stopping or reversing the life-altering and life-threatening complications of diabetes, even in patients in poor glycemic control despite following the most rigorous “tight control” treatment regimens.

PROVEN BENEFITS OF MRT INCLUDE

• Prevent or delay nephropathy
• Prevent or improve neuropathy
• Prevent or improve retinopathy
• Enhance healing of diabetic ulcers
• Prevent or reduce amputations
• Prevent or delay vascular disease

• Improve or prevent cardiomyopathy
• Improve or eliminate hypertension
• Improve orthostatic hypotension
• Restore hypoglycemic awareness
• Improve control in “brittle” diabetics
• Eliminate hypoglycemic reactions

• Regain energy
• Eliminate depression
• Restore sexual potency
• Improve sleep patterns
• Improve emotional stability

MRT TREATMENT INFORMATION:

1) The patient will initially receive treatments on two consecutive days when first starting MRT. Afterwards, MRT is given once weekly, usually on the same day of the week.

2) The night before MRT treatments, the patient will be instructed to reduce his intermediate and/or long term insulin doses, usually by 50%. On the morning of MRT treatments the patient will take NO insulin and NO oral diabetes medications. For his first few treatments, the patient will be asked to arrive at the center BEFORE eating any food that day.

3) In order to reactivate the enzymes needed for more proper metabolism, MRT requires higher than normal levels of blood glucose during treatment. At first, this is provided by drinking an oral glucola beverage. After your metabolism has normalized and stabilized, the patient will be permitted to eat a diabetic type breakfast before treatment, as well as have snacks during MRT. Additional glucola is given to provide the necessary glucose “signal” to the liver during treatment.

4) A pediatric sized intravenous access is started in the patient hand or forearm vein and attached to the MRT infusion device.

5) At the start of treatment, an initial blood glucose measurement is recorded and RQ (respiratory quotient) is measured by having breathe into a mouthpiece. The RQ is repeated at regular intervals during the treatment to document metabolic transition to more normal. Blood glucose levels are repeated at regular intervals to maintain glucose in the treatment range and prevent possible hypoglycemia.

6) Based upon the type of diabetes, body weight and usual daily insulin doses, individual pulsing profile is programmed into the MRT device. At the start of MRT, this dose is conservative. It will be advanced as your metabolism improves; treatment changes are made as your RQ and blood sugar levels dictate.

7) During the treatment hour, the patient will receive 10 pulses of insulin, each 6 minutes apart with blood sugars measured at least every 30 minutes. Measurement intervals may be shortened if there is  evidence of glucose changes requiring closer monitoring.

8) Following each of the three treatment hours, there is a “rest” hour during which no insulin is given, but glucose levels and RQ are closely monitored. The total MRT treatment takes approximately 6 hours.

9) At the end of treatment, the patients are monitored to insure blood sugars are stabilized and are encouraged to eat and exercise afterward. On non-MRT days of the week, the patient will monitor and manage his diabetes according to the instructions of his physician. Typically, blood sugars become more stable and doses of medications may need to be reduced. Many patients’ insulin needs are reduced 40% to 50%.

10) During treatment sessions, the patient can choose to read, use his laptop, watch DVD movies, socialize or simply relax. Treatments are given in a comfortable reclining style lounge chair. Most patients develop close friendships with staff and other patients and enjoy treatments as an important social outlet.